7, 8-Dihydroxyflavone / CAS: 38183-03-8 / Nootropics / Hydrate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: NJ0201019
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Transport Package: 25kgs/Drum
• Specification: 1kgs, 5kgs, 25kgs
• Trademark: Norky
• Origin: China
• HS Code: 2932999099
• Production Capacity: 10000/Month

Product Description

Product Description

7,8-Dihydroxyflavone

Other Name(s):

7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;DIHYDROXYFLAVONE,7,8-(RG);7,8-Dihydroxyflavonehydrate;7,8-dihydroxy-2-Chemicalbookphenyl-1-benzopyran-4-one;8-Dihydroxyflavone;7,8-DIHYDROXYFLAVONE7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on

OVERVIEW

7,8-dihydroxyflavone (7,8-dhf) is an effective and selective TrkB receptor agonist (KD ≈ 320 nm). TrkB receptor is the main signal receptor of brain-derived neurotrophic factor.

USES & EFFECTIVENESS

7,8-dhf specifically activates TrkB but not TrkA or trkC. In addition to cerebral cortex and hippocampal neurons, 7,8-dhf also protects other cells such as retinal ganglion cells (RGC) and PC12 cells from apoptosis and cell death induced by oxidative stress. Therefore, 7,8-dhf has neuroprotective effect. 7,8-dihydroxyflavone is a compound with biological effects. After intraperitoneal injection or oral administration to mice, 7,8-dihydroxyflavone can cross the blood-brain barrier and activate TrkB and its downstream PI3K / Akt and MAPK. 7,8-dhf can promote the viability of cortical neurons and reduce their apoptosis in traumatic brain injury. 7,8-dhf was administered 3 hours after injury. 7,8-dhf can reduce tissue injury through PI3K / Akt signaling pathway. The treatment of 7,8-dhf did not induce any obvious toxic effect in mice, and long-term administration had no toxicity to mice. 7,8-dhf has a strong therapeutic effect on Alzheimer's disease and can inhibit obesity by activating muscle TrkB.

 

Product Parameters

Product Name:	7,8-Dihydroxyflavone
Chemical name:	7,8-dihydroxy-2-phenyl-4-benzopyrone
CAS No.:	38183-03-8
Molecular formula:	C15H10O4
Appearance:	White powder
Storage:	Store in  2-8 ° C, dry, dark and sealed
Shelf life:	2 years
Package:	100g / bag / 3500RMB; 1kg / bag / RMB

Certifications

Packaging & Shipping

Company Profile

Shanghai NORKY PHARMACEUTICAL Co., Ltd., founded in 2006, is a leading manufacturer and supplier of Active Pharmaceutical Ingredients(APIs) and intermediates with a uniquely broad spectrum of innovative products and high quality. We are active in the development, manufacturing and
marketing of APIs and intermediates produced in our manufacturing facility in China under cGMP Compliance.

Our products are mainly focus on Nutritional supplement, food additive, feed additive, Hormones, and Amino acid, herbal extracts, API and intermediates, etc.

Our services and products will address our commitment to customers to provide the solutions they need to enhance their pharmaceutical business.

We will continue to explore new technologies and products and bring improvement to our APIs by offering regulatory documentation for our products; Our goal is to deliver high quality products and services on time to meet customers′ specification.

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