Abt-199 Powder From Factory Supply CAS 1228780-72-0

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: NJ0112001
• Certification: GMP, ISO 9001
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Product Name: Abt-199
• CAS: 1228780-72-0
• Molecular Formula: C19h27cln2
• MOQ: 1kg
• Appearance: White Powder
• Storage: Keep Cool and Dry
• Shelf Life: 3 Years If Proper Storage
• Shipment: Air Freight/Sea Freight/Courier
• Assay: 99%
• Water Solubility: Freely Soluble in Water
• Transport Package: 25kgs/Drum
• Specification: 1kgs, 25kgs
• Trademark: Norky
• Origin: China
• Production Capacity: 10000+

Product Description

 

Product Description

ABT-199

Other Name(s):
 
ABT-199;ABT-199(GDC-0199);GDC-0199;ABT-199100MG;2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)met;ABT-199,Venetoclax;ABT-Chemicalbook199(GDC-0199)Venetoclax;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]ami;Venclexta

OVERVIEW

Abt-199 is a new type of cancer drug, a Bcl-2 inhibitor, developed by AbbVie, an American pharmaceutical company. It is effective in fighting cancer and has fewer side effects than current drugs. The study was conducted by researchers in the United States and Australia. Related research results were published in the international journal NatureMedicine. Unlike common cancer drugs, the drug, abT-199, works by attacking an important protein called Bcl-2. Bcl-2 is one of the first members of the bcl-2 family of proteins that regulate cell death. It has been linked to many types of cancer, as well as some mental disorders and autoimmune diseases. In cancer, it is thought to act as a suppressor that helps cancer cells resist cancer treatment drugs. In cancer treatment, the pro-survival protein Bcl-2 can be used by cancer cells to suppress the therapeutic effects of conventional chemotherapy, which is often a headache for clinicians. Because cancer cells can use the pro-survival protein Bcl-2 to suppress the therapeutic effects of traditional chemotherapy, clinicians have to repeatedly increase the dose, resulting in side effects such as nausea, hair loss and Chemicalbook. The emergence of ABT-199 as a drug that can eliminate and reduce bcl-2 in cancer cells has led many clinicians to see the dawn of cancer treatment. Abt-199 is a novel anticancer drug that inhibits bcl-2 growth without affecting Bcl-XL, a protein essential for platelet formation. Overcoming this problem, in the history of cancer treatment is nothing short of jubilant. [Clinical trial evaluation] : A phase I clinical trial (NCT01328626) enrolled 84 patients with recurrent/refractory type.

 

USES & EFFECTIVENESS

Abt-199 showed low sensitivity to Bcl-XL, McL-1 and Bcl-W with Ki of 48nM,>444nM and 245nM, respectively. Abt-199 effectively inhibited FL5.12-Bcl-2 cells,RS4; 11 cells, EC50 of 4nM and 8nM, respectively, showed low activity on FL5.12-Bcl-XL cells, EC50 of 261nM. Abt-199 chemicalbook induced RS4; 11 cells exhibited rapid apoptosis, cytochrome C release, caspase activation, phosphatidylserine externalization, and sub-G0/G1DNA accumulation. Quantitative western blotting showed that the sensitivity of ABT-199 to NHL, DLBCL, MCL, AML and ALL cell lines was strongly correlated with bcl-2 expression. Abt-199 also induced CLL apoptosis with an average EC50 of 3.0nM.Abt-199 (100mg/kg) treated RS4; The maximum tumor growth inhibition rate was 95% and the tumor growth was delayed by 152%. Chemicalbookabt-199, either alone or in combination with SDX-105 and other agents, also inhibited tumor growth in DoHH2 and Granta 519 grafts.

Product Parameters

Product Name:	ABT-199
Chemical name:	Venetoclax Intermediate 1
CAS No.:	1228780-72-0
Molecular formula:	C19H27ClN2
Appearance:	White Powder
Storage:	Store in a dry and cool place.
Shelf life:	2 years
Package:	25kgs/drum, 1kg/Aluminum foil bags

 

 

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Company Profile

Shanghai NORKY PHARMACEUTICAL Co., Ltd., founded in 2006, is a leading manufacturer and supplier of Active Pharmaceutical Ingredients(APIs) and intermediates with a uniquely broad spectrum of innovative products and high quality. We are active in the development, manufacturing and
marketing of APIs and intermediates produced in our manufacturing facility in China under cGMP Compliance.

Our products are mainly focus on Nutritional supplement, food additive, feed additive, Hormones, and Amino acid, herbal extracts, API and intermediates, etc.

Our services and products will address our commitment to customers to provide the solutions they need to enhance their pharmaceutical business.

We will continue to explore new technologies and products and bring improvement to our APIs by offering regulatory documentation for our products; Our goal is to deliver high quality products and services on time to meet customers′ specification.


 

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